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How you do? 

1. Short for "How are you doing?" It can also be used for the pickup variety of that question, "How you doin'? ;-)"

2. Also short for "How did you do?"
(1)
Guy: How you do? Baby.
Girl: OMG, where did you learn how to speak? That's your pickup line? hahahaha

(2)
You: How you do?
Guy: I used the line that you told me, but she laughed at me. That was so messed up.
How you do? by w3source February 12, 2008
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how you do dis? 

A slang term that implies confusion and befuddlement. Often used when you have not been paying attention and you have to do a worksheet or test. This expression usually pisses people off.
"This worksheet is on standard deviation; how you do dis?"
how you do dis? by Chunky Reddy January 3, 2009

How you do that? 

When someone does some crazy shit and you just like
Joey; *draws Mona Lisa with some crayons*
Boing boing man; “AYO how you do that?”
Joey; “get good buddy”
Boing boing man (angry); “damn didn’t know that this was a boing boing situation ig”
Joey; “huh”
Boing boing man; “boing boing”

thats how you do 

thats how you do my n*gga

that's how you do its 

Unnecessary plural used for the word "it", otherwise meaning "that is how you do it".
Qoolz! That's how you do its!

how do you do? 

Somewhat archaic greeting. Was popular in England in polite society before the 50s.

The phrase is somthing of a non-sequiter - if read as written there's only half a verb, because one usualy does somthing rather than just does. The question could be construed as 'doing' your girlfriend or wife, but the intent is not to open a discussion on sexual acts, but rather to greet.
Jack: How do you do?
Jill: I am well Jack, and yourself?
how do you do? by Swamp Ig December 2, 2005

Tucson How Do You Do

When you kiss your friends dad while he’s on the toilet
Bracken: Oh yeah my dad is in the bathroom
Christian: Well in that case I’ll give him a Tucson How Do You Do!