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More colorful version of "What the fuck?" most often used when caught off-guard by loud sounds or animals flying past your face too fast to tell what they are; also during moments of self-reflection brought on by new sets of facts or personal epiphanies.
30 year old at Spring Break upon realizing he's a 30 year old at Spring Break: "Dufuck I'm doing here?"

20 year old at Spring Break upon seeing 30 year old at Spring Break: "Dufuck he's doing here?"

Everyone at Spring Break when DMX grabs the mic and grunts nonsensically: "Dufuck he just say??"
dufuck by publicationsamples May 15, 2014
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noun. A catastrophic defect that renders a product useless. Most common usage occurs in the software industry as a reference to critical defects.
When the customers clicked on the button, a defuck crashed the web site.
defuck by ktooth April 22, 2013
Related Words

Defuckify 

We need to defuckify this code set.
Defuckify by Mr Tiger April 28, 2015

DaFucketh 

When you do not truly understand the meaning of life. (occurs in an existential episode)

A term used by teenagers in a mid-life crisis.

Pronunciation: 'Da-Fuk-Eth"
"DaFucketh" - Reese while questioning how she got in the position where she has to find the products of NaOH + AgNO3
DaFucketh by Spankiness May 23, 2022

Defuckulate 

To take a problem situation that is seemingly impossible to coordinate or rectify, and create a working solution that is satisfactory to all parties of interest.
"The Boss said to defuckulate your work backlog today, or you'll need a federal bailout for your next paycheck!"
Defuckulate by Mister Bee February 7, 2009
(v): to not finish your beer
Paul dubucked his beer, again!
Dubuck by Block Island Gang February 17, 2015
Also "De-Fucked"
The antonym of fuck, used as in "getting fucked up"

To reverse the procedure of getting fucked up.
To restore to good health.
To rehabilitate.
To repair to a usable or presentable condition.
That dude is in the hospital getting defucked up after getting the shit beat out him.

This chick was totally stoned so she had to go get defucked up.

Wow, those geeks totally defucked that computer that I thought was a complete piece of shit.
Defuck by Okix25 December 17, 2010