The phrase used to break up with that person (usually a boyfriend or a girlfriend) who is toxic to you. It keeps it simple, the best way.
"What do you mean you're not coming over on Saturday night? What else do you have to do? We always watch basketball or hockey or football or (worse yet) golf, and you bring the pizza and beer, and we hang."
"Not this Saturday night or any other night after that, Fred, you deplete me. Mind, wallet, and soul. Buh-bye."
2 - the panicky paranoid state of mind which inspires one to go through old emails, texts, etc, deleting anything which may be vaguely incriminating
I found my girlfriend going through my phone, but it's ok cos I got a bit deleterious last week and wiped those drunk text messages to my ex from my outbox
When you have to pee in a movie but don’t want to miss anything, and must do the following mental equation: will the amount I have to pee cause enough discomfort to diminish my attention capacity for the remainder of the movie to an extent which is greater than the amount of the movie I would miss by making a mad dash to the restroom.
I saw Satantango last night, wonderful film but by the 5th hour I had to start doing pee calculus.
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).