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The opposite of hope. It is something that hope will always defeat.
It is also something Nagito Komaeda dislikes.
We'll never give in to your despair.
Despair by hopebagelko June 30, 2017

Departia 

Pronounced: (di-PART-shə)
A temporary disorder of the mental processes caused by vacation being less than one week away. Those with DEPARTIA typically exhibit lack of focus, impaired judgement, and incessant talking about their plans to co-workers.
Origin: from "depart", derived from "Dementia"
First used by TV Meteorologist Andrew Freiden
Don't rely on Tracy to file that TPS report on time. She's off next week and the departia has kicked in already.
Departia by GreatIdea June 19, 2014

department of the interior 

Department of the interior yet another name for Vagina
I'm hoping to see the department of the interior tonight
A word meaning the complete absense of hope, popularized among pop culture by the video game series Danganronpa.
Person: “I’ve sunken into despair; I dropped my donut.”

Mukuro Ikusaba, the 16th student, lying hidden somewhere in this school. The one they call the ultimate despair. Watch out for her. 

Mukuro Ikusaba, the 16th student, lying hidden somewhere in this school. The one they call the ultimate despair. Watch out for her.
Mukuro Ikusaba, the 16th student, lying hidden somewhere in this school. The one they call the ultimate despair. Watch out for her.

Departure Lounge

A poo store just behind the sludge valve. Where little Chocolate Hostages sit awaiting their release.
I have a little Chocolate Hostage sat in teh departure lounge, better find a crap trap quick.