Slang Jon Stewart often uses for the flu or common cold.

Based on the way he pronounces it (tongue-in-cheek Godfather character accent) it's probably the plural form of the Italian word 'bubbone,' a swollen lymph node characteristic of bubonic plague. It probably developed as slang for an infection because bubonic plague is so infectious. Stewart probably picked it up growing up in the NJ/NY area.
"I have the bubons again. It's the second time in three months. Let me say this to anybody out there with children at home: buy an autoclave."

Jon Stewart
The Daily Show
February 22, 2011
by TDSFan123 February 26, 2011
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"I got some bubonic product and then we chilled for a bit." -Snoop Dog
by Laura February 21, 2004
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1. Slang/ebonics translation to the word Bubonic plague.

2. Sickness
3. A person who spreads diseases to others.
That man got my little baby daughter sick. The guy is a bag of bubonics.
by ogmedia February 2, 2012
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noun, a severe cold or flu that's kicking your ass, usually caught from kids who bring it home from pre-school.

Made famous by Jon Stewart on The Daily Show.
"Did you see the Daily Show last night? Jon Stewart had the bubons, he could barely interview that guy."

"I can't go out for drinks, I've got the bubons."
by zen velo March 3, 2011
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viral to the point of being ridiculously over-saturated
Post a link? Seriously? It's already gone bubonic.
by NJtoTX January 16, 2014
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Absolutely deadly adjective to add when someone gets roasted.
Thing one: Goddamn this kid looks like a garlic goblin

Thing two: Bro that was shii was absolutely bubonic 💀
by Acri April 8, 2022
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Adjective, meaning extremely cool, tight, sweet, or sick.
This new cell app is bubonic!
by tracydavekport June 9, 2009
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