Sighence Share definition Flag Sighence (Noun say Sigh + ince) Reference to 'Science' with a boring tone. Brother: What are you studying? Me: Sighence....... Brother: haha, shame. Sighence by eXploit February 18, 2009 0 0 Get merch Get the Sighence mug. Buy Now — $32.95 See more merch