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O'Brien's Law 

Named after famous journalist James O'Brien of LBC, O'Brien's Law states that a centrist, when cornered, will always blame Jeremy Corbyn regardless of the facts.
James couldn't get it up, and so he blamed Jeremy Corbyn. Thus O'Brien's Law was born.
O'Brien's Law by Corbynista March 24, 2021

O’Brien’s Law 

You think Murphy’s Law runs strong on your bad days; my cousin’s bad luck runs on O’Brien’s Law. His bad luck runs so deep it makes Murphy look like an optimist!
O’Brien’s Law by ctjstr September 8, 2021

Ethan O’Brien Syndrome

To be a fucking fatass idiot who loves to suck men off
Hey kid, u have Ethan O’Brien Syndrome

Mr. O'Brien Science Brainrot

The Mr. O'Brien Science Brainrot is a subculture, religion, manuscript, and "disease", based on the life of Russell O'Brien. Due to his high-pitched voice, a voice recorded file of a Mr. Hanky soundin ahh fella went viral within New Zealand, bringing the group into popularity.
"William and Arman's conversion to the Mr. O'Brien Science Brainrot group changed my perspective."
"The legend of O'Brien's breakout of an ISIS facility through rat atom manipulation inspired me to convert to the Mr. O'Brien Science Brainrot"

Sam O’Brien 

Sam O’Brien means
Can’t run for shit but he can hit a ball with a stick

Soledad O'Brien 

An extremely talented and hard-working person on CNN. She hosts Starting Point in the morning and sometimes fills in for other CNN hosts at night like Anderson Cooper. In other words, she is extremely amazing. She is married to Bradley Raymond, director of some Disney movies like Lion King 1 1/2 and Pocahontas II.
Guy 1- Hey, were you watching Good Day New York this morning?

Guy 2- No way! Starting Point with Soledad O'Brien was on! I watch it everyday!

Guy 1- OMG! I know her! She filled in for Anderson Cooper for an entire week last August!

Guy 2- She's wonderful!

Guy 1- IKR!
Soledad O'Brien by I Love AC September 26, 2012