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To murder, kill, or otherwise destroy. Derived from the word "mercenary".
If that mothafucka look at me like that one more time, I'm gonna merck somethin'!!!

Jay: Yo Wally, nice haircut, asshole!
Wally: Fuck you bitch, I'll merck yo' ass.
merck by ACNY August 23, 2006
Related Words
to kill, murder, end the life of someone else.
first D got mercked, then rob got mercked, and homie still in the hood, y he ain't got hurt?
merck by ebkbk May 19, 2005

Merckial 

to conquer a game; to be good at a game; to be professional

young kids these days call it "being pro" or from the Latin word "professional"
I just started playing this game, then I realized that I am actually merckial at this.
Merckial by Krxsty_Erxs November 15, 2020
I’m sorry for your loss
“Merck”
OR
I love this song
“Merck!”
Merck by GangGang4206_9 October 26, 2018

Merckoff 

The employees and subcontractors who work at Merck in West Point (Lansdale), PA and Whitehouse Station, NJ. These people drive like assholes while talking on their cellphones and totally disreagarding traffic laws and common coutesy. They speed through residential neighborhoods going to and from work. When they frequent local businesses they are loud and obnoxious pissing and moaning about their co workers, bosses, and subordinates.
Those Merckoffs stayed for hours, got separate checks, and then stiffed the waitress.

That Merckoff in the silver BMW came flying around the corner and then rode my ass all the way to the traffic light.
Merckoff by Mattryes February 6, 2009
A word used to state/signify one of the following situations:

A. To be physically, mentally, emotionally, or verbally demeaned in a given situation.

B. To be high on drugs. (Usually marijuana)

C. To be drunk.
A 1. (A man is playing football and is hit so hard that his helmet was knocked off)
Teammate- "You got mercked, dude"

A 2. (A pair of boys are arguing over a girl.)
Boy #1- "Dude, stop hitting on my girl!"
Boy #2- "Man, I gave that girl the clap, have fun with that!"
Bystander- "Mercked."

A 3. (A boy is picking on a weaker child)
Boy- "Look at how small you are! I can hardly see you, little guy!"
Weaker boy- "That's not what your mom said last night!"
Bystander- "Mercked."

B./C. (A man is walking around aimlessly. He sees a friend of his.)
Friend- "Hey man! I think I saw you at a party last weekend!"
Walker- "Man, I went to that party and got so mercked."
Mercked by IsHottleThere May 17, 2010