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To perform a sexual act on another individual on public or group transport (such as a bus, train or plane). Sometimes but not always by a girl named Melissa.
"I fully saw this girl give this guy a Melsy on the train the other day"

or

"We were all so drunk on the way back from the wedding that Mel gave James a full 'Melsy' in front of everyone"
by DJ Japeye January 28, 2019
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2
an amazing and creative nickname for the name "Melissa," also used, in general, to describe loving, but klutzy women.
*upon meeting a girl named Melissa*
"o hai melsy!"

or

*upon seeing a girl fall in gym class*
"that girl is such a melsy"
by eyo Oy February 25, 2010
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