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Lolectomy 

1. Something that severely pisses you off that you lose your sense of humour.

2. Something that is so seriously unfunny that it cuts you off mid-laugh.
Dude you should not have deep fried my new ipod, it has given me a serious lolectomy.
Lolectomy by Zeddie June 2, 2009
Related Words
The act of removing a lid stuck on an animal.
I performed a lidectomy last night after a hedgehog got his head stuck in a McFlurry cup lid.
Lidectomy by Daniel_NZ January 27, 2022