Slang for drug peddler, in other words: A dude or dudette who dabbles in the rough and dangerous world of selling illegal (sometimes legal) substances.
"Get that damn drugler out of my damn house! Or Imma kick you out, you got that son?!"
A 22 ounce bottle of beer. Clyde "The Glide" Drexler was number 22 on the Portland Trailblazers for many years.
PDX Hipster #1: What do you want to do tonight?
PDX Hipster #2: Pick up a couple Drexlers and listen to mediocre indie rock?
PDX Hipster #1: Sounds fly.
PDX Hipster #2: Fly? Really? 1987 called, it wants its slang back.