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all up on 

(def 1) On top of, either in a literal or metaphorical sense.

(def 2) Pursuing or showing interest in.

(def 3) Imminent or present.

Cultural note: This phrase has received some popularity due to it's occasional use by the character Strong Bad on the Homestar Runner website.
(def 1) George had three puppies, and every time he sat down to watch TV they were all up on his lap.

(def 2) Commercials would have us believe that a guy just has to use the right brand of deodorant and the ladies will be all up ons him.

(def 3) So it's finally Halloween and the Autumn months are all upon us.
all up on by Peter K. September 14, 2007
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all up on 

Used to mean an encroachment of personal privacy or space, invited or uninvited. Some form of pressure, either physical or mental, i.e. a woman dancing really close to another guy; a landlord pressuring for rent.

Can be used to imply sexual interest, as in someone who is intensely flirting/mackin on someone else, either physically or figuratively. Implies intense or clear sexual interest and pursuit. Same as all over him, related to all up on his balls or all up in his business. Can be used for both genders (i.e. he was all up on her)
Girl was all up on him in the club, backin her booty up.

She was all up on him, wouldn't leave him alone, tryin to get his number n shit

Damn, why you all up on me? I'll get you your shit, I swear.
all up on by ptree March 25, 2008

all up on your sac 

in your business...nosey...

related to the phrase "get off my nuts"
man, he was all up on my sac about that shit.
all up on your sac by jase February 11, 2005

all up on my jock 

The act of trying to flirt with someone extensively, what one who is tyring to flirt does to the one who is being flirted with.
"That chick we met last night was all up on my jock, yo." (That girl we met last night was shamelessly flirting with me.)
all up on my jock by Kelly McMuffin September 29, 2004

all up on my balls 

Up in someone's business, getting on someone's case, harping on someone, aggressively invasive or pursuant. Can be used to mean a woman whose aggressively pursuing a man. Can also be said all over my balls or just on my balls, or in terms of get off my balls or get off my back
My landlord was all up on my balls for the rent this month, dude needs to chill out

Your girl was all over your balls last night at that party

Man, why you all up on my balls, I already said sorry

Dude, get off my balls about it
all up on my balls by ptree March 25, 2008

all up on him 

Next thing ya know she’s in the pool, wet, talkin’ dirty and all up on him.
all up on him by allupon him July 20, 2003

All up on my Cupcakes

When a guy hits on a girl.
God Sarah, that guy was all up on your cupcakes!
All up on my Cupcakes by BL April 7, 2005