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thwacked 

thwacked is the condition your mind is left in after habitual drug use even after sobering up. a thwacked individual will behave differently than they would have if they had never consumed drugs, the most common being drug seeking behavior AKA fiending but also lack of common sense, decreased intuition, degraded performance, etc. opioid use disorder is a an example of a thwacked condition but ALL drugs (from weed to wellbutrin) have the potential to thwack you one way or another if you fail to moderate usage. the only treatment is time but in some cases prolonged drug use may leave you with permanent brain damage and you will be forever thwacked.
i was so thwacked i bought $5000 worth of oxycodone but then had a moment of clarity after i got fired... wanna buy my pills?
thwacked by steg0saur January 19, 2020

twacked out 

when you've been up for forever on meth and are starting to trip hardcore - ie, when your face is beginning to become one giant open bleeding sore from picking at it.
"damn, i am so twacked out, i plucked until i dont have any eyebrows left."
"your pupils are so big you dont have any color in them - you're hella twacked out."
"for the last time, that is a MINIVAN, not the FBI - quit getting so damned twacked out!"
twacked out by The KKK December 21, 2004
A state of mind in which methamphetamine intake has occured to beyond the point of tweeking.
I was so fucking twacked.
twacked by Richard Deep February 26, 2003

Side twacked 

Play on the term sidetracked: When a person gets too spun out on meth and they cant seem to focus on the subject or task at hand
Tyler is always getting side twacked
Originated in Stillwater, Oklahoma in 2000. When you've done too much tweak to the point where you are useless to the world. When you are so spun that you are get caught in the same repetitive motion until you run out of crank.
Damn, Tamara's been working on that crossword book for 3 days straight, someone take her dope away, she's twacked the f&#^ out.
twacked by Ziggity February 21, 2005

twacked out 

When you're really high on meth or when you've been awake so long smoking dope that you're totally outta there! My friend was so twacked out on dope he thought that I was a cop.
I can't understand what the fuck you're saying cuz you're talking 100mph you're so twacked out.

I was so twacked out I thought there were undercover narcotics agents in the van parked across the street.
twacked out by Bowl Roller August 23, 2010