shutuppl Share definition Flag A lazy and short way for saying shutup ppl. Generally used to silence audiences. When i was doing a lab with my cohorts they wouldn't stop messing around so i typed "shutuppl" so they knew i meant buisness. shutuppl by depender March 4, 2016 0 0 Get merch Get the shutuppl mug. Buy Now — $32.95 See more merch