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Sayonara Zetsubou Sensei

Probably one of the weirdest manga ever penned by the Japanese. Written by the satirist Koji Kumeta, it tells the tale of one Kafuka Fuura, who discovers her teacher, Nozomu Itoshiki, under a sakura tree...

He is hanging by the neck in one of his many suicide attempts. She, being endlessly optimistic, thinks he is simply trying to make himself taller. Needless to say, this is where things get quite strange...and hilarious.

He teaches a class full of strangers, from the hikikomori, to a Disassociative Personality Disorder suffering transfer student, to a stalker, to a ridiculously OCD psychopath. And a normal girl.

The series does not take itself seriously at all, and is probably the darkest, strangest, and most disturbing comedies in existence.

AND I LOVE IT.
I'M IN DESPAIR! THE FACT THAT SAYONARA ZETSUBOU SENSEI HAS ENDED HAS LEFT ME IN DESPAIR! THERE'S NO HOPE! I'M GOING TO GO DIE!
Related Words

Honey Senpai 

Tiny little shit that can kick your ass.
Me: Damn, honey senpai is 17, yet he acts like a child. That little shithead.

Honey: *climbs up to my room window*

Honey: I heard you were talkin shit about me.

Me: WTF-

Honey: *kicks my ass and I end up in the hospital.*
Honey Senpai by Annie May Tidday December 2, 2018

rusty sensei 

Someone who is a master of all things rusty and has supreme knowledge and experience in this specialized non-procreative area.
I yielded in great deference to the rusty sensei as he waxed eloquently with great depth and breath on bold concepts as the rusty trombone to the rusty ride to 50 shades of rust.
rusty sensei by sbp1029 November 7, 2013

Hentai Senpai 

Master of Hentai. Tends to spend all free time watching anime porn. But you can't be just any watcher of hentai. To become master you must wank uncontrollably for an entire day. Then and only then will you be Hentai Senpai.
Boy 1: Hey look at that nerd over there! I bet you he has no friends!
Boy 2: Are you kidding? That's Hentai Senpai. He may not have friends but so many guys look up to him! I can't wait til I can one day become like him!
Boy 1: He's still a nerd.
Hentai Senpai by silverwin February 12, 2014

Yajuu Senpai 

Japanese gay pornstar. Despite being the most famous gay pornstar in Japan, his identity is still yet to be located. Famous for his scream.
I spend my weekend watching Yajuu Senpai MADs on Niconico Douga.

Senpai withdraw 

when you slowly go crazy due to the withdraw of senpai
I was but in a mental hospital due to senpai withdraw