"That is off the hook for real" would be the literal meaning of the phrase. It means that something is extremely novel and interesting, and that you're dumb enough to think you soundcool adding "izzle" to the end of your words.
Dude A: Hey dude, have you seen Frank's new car?
Dude B: Why yes I have. That tizzle off the hizzle foshizzle.
Dude A: WTF?!?!?!
Someone or something that bites your ankles.
To a postman, an ankle biter is often known as a dog.
To an adult, an ankle biter may be a toddler.
To hikers, an ankle biter is sometimes a tick.
And so on.
When a manwill search for hours to find something that is laying out in the open on a table. Items are often easily found by a women.
Man: "I have been searching for hours for keys."
Woman: "You mean the ones sitting there on the coffee table?"
Man: "Where?"
Woman: "Right there in the middle of that table."
Man: "oh, must have been Male Pattern Blindness"