It has two meanings, 'Sure' and 'Shit'. It all depends on the way you say it.
Sure - 'Fo Shizzle' = For Sure, Definately

Shit - 'That's The Shizzle' = That is good.
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a word which is funny to say when you get bored, you can randomly say shizzle, and then if the person you're talking to has any brain cells they will say on da hizzle or something completely pointless and stupid like that, it is weird and lame but it fills up hours (it works best if black people say it, i don't know why) and then when you get sick of this pointless crap you can say bizzle which sounds a bit like bye or gizzle (going) or gizzle fizzled nizzle (get fucked noob)etc etc
me:fo shizzle
dude: on da hizzle
me: zizzle
dude: frizzle mizzle
(four hours of pointless moronic izzle noises ensue)
me: gizzle fizzled whizzle
dude: bizzle
me: (unable to bear it any longer)SHUT UP!!!!!!!!!!
by Moominbaybee May 29, 2008
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this means it's a for sure thing
Were going to your house after the movie for shizzle!
by okiefrommuskogee August 3, 2006
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Word most often abused horribly by inexperienced suburban white douche-bags who wish to give themselves some falsified counterfeit form of street-cred. Also used by the oreo cookies who stoop low enough to keep the company of these pathetic weasels.
"Say, Toby, would you like to purchase that new funky fresh cd by Ruben Stoddard?"
"Why sure, Justin, fo' shizzle my nizzle"
by Prince October 18, 2004
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1. Sure, as part of the phrase 'for sure,' for example.
2. Shit, as part of the phrase 'tha shizzle,' for example.
"Fo shizzle" = "for sure." "Tha shizzle" = "the shit" or something good.
by KingFatty March 25, 2005
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