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father's brother's nephew's cousin's former roommate 

Someone whom you have no relation to in genealogy. A joke in the movie Spaceballs
"I am your father's brother's nephew's cousin's former roommate"
"And that makes us?"
"Absolutely nothing! Which you are about to become!"
(Quote from Spaceballs)

Throw Me That Pigskin Nephew 

Pigskin referring to a decoy grenade in the video game Counter Strike Global Offensive.
"yo yellow, Throw Me That Pigskin Nephew"

"Blue 22' Blue 22, hut hut hike. toss me that pigskin nephew, toss me that pigskin!"

Nephew Bop 

The Nephew Bop is a "dance" popularized by Samm which consists in acting like paramedics are performing CPR on your ass (Zings nephew went out cause of a cardiac arrest).
Zings Baljeet The Third of Timbuktu, which nephew got spawn killed (not even after 3 months of life) in a hospital bed is now on the verge of pulling a "zings sister".
(Note: Zings sister unalived herself after the "loss" of her son)
"bro what you think bout zings gettin exposed for watching hentai?" "Nephew Nephew bopping punching my hips"

playing with the bishop's nephew 

"playing with the bishop's nephew" is the act of masturbating while taking a shit in public. in modern usage the term also covers the act of masturbating while shitting in private, however the public aspect of the activity is of no small importance.
derek: "hey ronny, what's happening?"

ronny: "ah nothin', just hangin' at the crib."

derek: "well, you wouldn't believe what happened to me today- so i was up at colombus circle waiting for the bus, just playing with the bishop's nephew, and next thing you know this bitch starts flippin' out."

ronny: "what'd you do then?"

derek: "i told the bitch to chill the fuck out, i'm just playing with the bishop's nephew."

ronny: "sounds reasonable enough."
Snoop started using nephew to try and get people off of using the n-word all the time. Means the same (ie brother), but in a less aggressive/derogatory sense.
what's crack-a-lackin nephew??
nephew by jerome November 21, 2003

wray and nephews 

the most hardcore spirit one can find in a local pub, mostly weatherspoon branches. not for pussies.
yo dude, i have no will to live, wanna get sum shots of wray?
wray and nephews by TuBsy February 16, 2005