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Shorthand term for Mandrax (pronounced "Mandrakes"), a line of highly addictive British pharmaceutical tablets no longer in legal production. They act as barbiturates (or "downers") and were prescribed as sleeping aids in the late 60s and early 70s. They are prevalent on the drug market in many African countries, as well as a few south Asian countries. As Mandrax was initially produced in pill form and meant to be taken orally, many abusers ground up the pills and smoke them with Dagga, because like most other illicit substances, the effects are greatly enhanced when snorted, smoked, consumed in conjunction with alcohol or injected into the bloodstream. Short-term side effects are not much worse than your average anti-depressant (cramps, headaches, emotional problems, etc.) but loss of muscle control (resulting in the user suddenly collapsing) and toxin-induced psychosis have also been found to result from Mandrax use.
"Wanna buy some mandies, Bob?" - Frank Zappa, "Flakes"
mandies by Siegfried Zaga May 22, 2005
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Slang for Mandrax, the British brand name for the sedative methaqualone, also sold by Rorer (later Lemmon) as Quaalude. A very popular drug of abuse in the late 70s but was eventually placed on DEA Schedule 1 and is no longer in manufacture.
Wanna buy some Mandies, Bob? -- spoken by Frank Zappa in the song "Flakes" on the album "Sheik Yerbouti"
mandies by Johnny Watt December 30, 2012
The guy version of a figurative panties/undies. While no male panties have been made, this formless 'wear' is used by men and boys.
To be used when one is under such astonishment, that his mandies are dropped Oh sh*t these cigars are so good, I creamed my mandies. Dropping my mandies
Mandies by Herfar December 11, 2014
a generation of male television journalists that care less about answers and more about exposing personality in their reports. They were inspired into "journalism" by the person who asked President Clinton, "Boxers or briefs?" Comes from the phrase "Man Candy."
Carson Daly, Billy Bush and Ryan Seacrest are the Mandies who want their name to be part of their subject's answer.
mandies by Joe Corey May 14, 2004
Bro did you see his underwear?

No.
Well he was wearing solid gold Mandies and they were the ones I saw on eBay for 1.3 billion dollars.
GASP
HOE I KNOW

Sandies for me mandies 

Said when presenting a tray of sandwiches for a group hungry men. Irish in origin. Used in the gay community. When a man courting several men tries to win their love through their bellies.
Here you go my hungry fellows. A fresh tray of sandies for me mandies; courtesy of Paul.
Male panties. For the progressive man or your everyday cross dresser.
"I'm wearing my new manties today, and I'm chafing hardcore bro!", or "Dude, is my mantie line showing", or "I forgot my swim trunks, I'll just wear my manties in the pool"
manties by Jermaine90210 January 15, 2010