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Los Santos 

Los Santos is the city with the highest crime rate in the U.S . The city of Los Santos was founded in 1781. Los Santos is the largest city in the U.S state of San Andreas.
Los Santos by Würstelchen May 3, 2020

Los Santos Institute of Roastology 

A high-end university run by Lamar Davis which teaches its students the science of roasting, especially yee-yee ass haircuts. It is located in Los Santos, San Andreas, USA.
Person 1 : Can i come to your house?
Person 2 : No, we will meet tomorrow at work
Person 1 : Ah man, don't hate me because I'm beautiful man, maybe if you got rid of that old yee-yee ass haircut you got

you would get some women craving for your penis. Or better yet, maybe Tanisha will call your desperate arse if

she stops enjoying coitus with that brain surgeon or lawyer she is making love with. NIGGAAAAA
Person 1 : what?

Person 1 : Do you go an university or do you work?
Person 2 : I go to the Los Santos Institute of Roastology

Los Santos Customs 

A chain of vehicle customization shops in Grand Theft Auto V. Has a spray can icon on the minimap.
I just customized this Warrener in Los Santos Customs.

Los Santos Stomp 

A method of execution in GTA V Online whereby one disables a Deluxo’s hover mode in midair, causing it to fall on an unsuspecting victim and crushing them like a bug beneath a boot.
"See that griefer down there? How about we fly over there and give him the ol' Los Santos Stomp."
Los Santos Stomp by CapedCamish September 24, 2020

Los Santos Roleplay

A very shitty roleplaying game on the San Andreas Multiplayer mod for GTA San Andreas. Consists of mostly scammers, robbers, gang members, and policemen so there's not much of a variety. You work hard for your money and to end up getting it all robbed at the end. Yup, even the policemen jail you and ticket you for no reason just to earn money. The game also consists of 9 year old admins and players, so if they don't get what they want they be a bitch about it. The economy really sucks ass too because there are billionaire gang members and millionaire policemen. They're all e-money hungry. Most of the houses are taken by players who quit or never log on anymore.
After fishing and working hard for money for a long time:

Robber:(holding gun up to you) GIMME UR MONEY OR I KILL YOU- AND DON'T LOG OFF OR I REPORT YOU

Hard Worker gives Robber his money.

Robber: HAHAHAHA THANKS NOOB ALL YOUR HARD EARNED MONEY IS MINE NOW!!!!111

Typical day in Los Santos Roleplay
Los Santos Roleplay by LSRP Sucks January 11, 2011

Los Santos Rock Radio 

Spack No.1, I would like to thank you sooooo much for getting me into Spack music by putting on Los Santos Rock Radio when I was in your car on GTA O on one fine day!