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The sensitive, vital part in the neck.
Dude, you just took one in the jugular!

Frank: You're crazy man, I like you, but you're crazy!
jugular by tim May 2, 2006

going for the jugular 

Attempting a fatal attack against an adversary. An attack intended to completely defeat and destroy one opponent, most particularly by attacking their vital weakness as if trying to sever the jugular vein.

The tactical opposite of "going for the capillaries."
In Star Wars, Luke Skywalker defeated the Death Star by going for the jugular and firing a proton torpedo volley into its main reactor, causing a chain reaction that destroyed the entire station.
going for the jugular by MaxwellX September 3, 2010

jugulars 

My God! Check out the jugulars on the chick at the counter!
jugulars by Mo Dixley December 29, 2004
Someone's neck. Injuries to this area are often fatal.
Beka: I'm so metal that when I was born, I bit the doctor in the jugular, 'cuz that bitch tried to spank me!
Jugular by Ethan J. January 17, 2008
how to kill a man in 3 secs
"straight for the jugular"


(vein, throat liver, thorax, big toe, hyperdermis)
jugular by ROYSTER May 8, 2003

jugulate 

i'ma jugulate you, you trick-ass motherfucka
jugulate by Tim April 7, 2004