Attempting a fatal attack against an adversary. An attack intended to completely defeat and destroy one opponent, most particularly by attacking their vital weakness as if trying to sever the jugular vein.
The tactical opposite of "going for the capillaries."
In Star Wars, Luke Skywalker defeated the Death Star by going for the jugular and firing a proton torpedo volley into its main reactor, causing a chain reaction that destroyed the entire station.
12 step recovery jargon referring to someone new who talks about how great life is, now that they're sober. Usually meaning that the person is out of touch with reality.
The new guy seems pretty happy for a dude who has no job, no money and no family. He must be on a pink cloud.