five - o Share definition Flag A generalization of the name of the Honolulu Police (as in the old TV program "Hawaii 5-0") to refer to any police agency or generic cop(s). Douse that doob, man, the five - o is on our ass! five - o by LYQUOR July 19, 2007 0 0 Get merch Get the five - o mug. Buy Now — $32.95 See more merch