Person 1: "James, why the fuck are you eating on the toilet?"
Person 2: "Good question brother. Why would you eat and shit in different places? I'm just being effi-shit."
A metaphorical drug which allows a person to stop being affected as much over a negative or stressful event, essentially allowing them to think 'eff it all.'
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.