Internet's Down Syndrome 

A temporary condition brought on by the lack of internet connectivity and characterized by irritability, fidgeting, lack of focus, a general feeling of helplessness and occasionally exercise.

Steve: What's up with the glazed look on Meredith's face?

Brad: Well, she likes to start her day reading Perez but we have no connectivity and slipped into an acute case of Internet's Down Syndrome.

Internet's Down Syndrome by Motorbeard April 24, 2008

Down's Quindrome

A condition affecting one in every 7 billion people. Symptoms include giving people second hand mental AIDS, perpetual idiocracy, inability to formulate one complete sentence, and an exponentially decreasing pass accuracy.

Wow, Down's Quindrome really hit that child hard.

Down's Quindrome by Not Quin April 21, 2017

Double Down's Syndrome

A sickness developed while playing Blackjack that causes you to risk all your chips constantly from doubling down.

Jim lost all of his money at the casino yesterday after getting a case of Double Down's Syndrome.

Double Down's Syndrome by Bob The Larry July 11, 2011

Lay down some G's 

Shahbaz's phrase for putting thousands of pounds towards something.

Guy: I went to a club on Saturday and got a table...
Other Guy: Bet you had to lay down some G's....

Lay down some G's by XXXXXXXXXXXXXXXX March 17, 2014

down’s syndrome 

some of the most amazing people on the planet who are actually extremely intelligent (coz sum of y’all clearly aren’t, throwing shade) and hilarious and beautiful and wonderful human beings. take it from me my sister has it. no it’s not a fucking disease, nothing reduces or amplifies it, you can’t catch it (wtf), people with it don’t suffer, and they’re something funny cute and awesome! so for all y’all insulting people by calling them down’s syndrome, a) find a better insult, b) get a fucking life, c) google it before you use it to be mean and d) think about how other people who know people with down’s syndrome actually feel about you using language like that?!

see that girl over there, she has down’s syndrome, look how happy she is. she looks like so much fun

down’s syndrome by belladanke November 13, 2018

down's syndrome 

Even god finds them funny.

Down's syndrome kid: "Help me, my eyes are r8 small but ma head's pure massive"
Guy watching: "Hahaha oh my god you should be put down."

down's syndrome by sdw298 May 5, 2008

Amber Down’s syndrome 

A very rare serious disease that shouldn’t be taken lightly. Symptoms include;
- shitting yourself
- kidnapping people’s pets
- constant Facebook live sessions

- masterbating with pliers

- stealing peoples boyfriends/ex’s
- feeding pets bath bombs

“Shit I’ve caught something I’ve been to the doctors and they’ve diagnosed me with Amber Down’s syndrome it’s incurable”

Amber Down’s syndrome by Syndromedisease February 9, 2018