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adverb. a synonym for the word definitely. used to express complete agreement or strong affirmation.
guy #2: dude you wanna come to my party, it's gonna be super sick!
guy #1: defferson!
Defferson by Brent Handles January 23, 2009

Duffers' Syndrome 

A slang term for the very serious medical condition duphershypertrophy whereby the sufferer acquires over time excessive fatty tissues to the nasal region, giving the patient the not unpleasant features of a gnomish looking fellow; rosy cheeks from the strain of holding one's nose up all day, at times somewhat gormless facial expressions (which can be attributed to the drag-factor but more often can lead an innocent bystander unaware of the condition to conclude that the sufferer is possibly some sort of simpleton) and of course the ever-expanding, bulbous nose which grows and grows like in that fable about the enormous turnip...

Prognosis: Not good; rhinoplasty recommended.
What are you doing resting your nose on that snooker cue? Have you got Duffers' Syndrome or something?
Duffers' Syndrome by Mouldy123 April 3, 2011
m is short for most or mos
m deffer is most definately
mos def is m deffer because deffer is short for definately
m deffer by 99pl April 24, 2007

delferson 

He is a bright boy. A good friend. Tall asf & would make anyone’s day better by a wave of his hand. Delferson is weird but in a fun way. He means everything to his friends. I don’t know if theres other Delfersons but i cherish mine. Delfersons are amazing, funny, and caring & someone you don’t want to live without. If you come across a Delferson KEEP THEM IN UR LIFE
someone: Omg he’s so funny
me: He’s Delferson
delferson by cherrypoptartg October 20, 2020
a totz radder awesomely awesome way of saying definitely.
:)
jeanine: cherie is totz smelly
cody: defferz
defferz by Jeanine Howton June 27, 2008
1. An expression to refer to those Americans who live unexciting or unexotic existences. Typically used by truckers, construction workers, or others whose livelihoods aren't geographically dictated.

2. Boring middle class white people who live in suburbs.
Sam: All they do is bitch about their commute.
Bob: Of course. They're duffers. That's what they do. That's their biggest problem.
Duffers by mathias83 March 12, 2008