A person so nuts or "ape-shit crazy" that they disturb peace, daily life, and very possibly the very fabric of the universe.
OMFG! Mrs. Puttana is such a crazy ass mother fucking bitch for giving us a eighteen page essay over Winter break! How I am supposed to enjoy my childhood like this?!
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.