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People who are paranoid, delusional, uneducated, and covered with oozing chemical scabs and ulcers due to the acute abuse of methamphetamine. They eventually eat scabs from one another that contain the meth that their body can't dispose of, just to catch a cheap thrill. MMMMM....MMMMMMMMM!!!
I called the DEA the other day on those tweakers down the street.
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Methheads. Named for their twitchy, "tweaky" behavior.
"Those goddamned tweakers make me nervous to be around"
tweakers by Rokki J. Rand November 2, 2007
A people who uses the drug methamphetamine. A low life piece of shit. Someone who will steal from you in order to score meth. Zombie like
I was watching the video "tweakers" by skinny mumbles on YouTube.

The tweaker beater mafia is coming to town to get rid of our cities meth problem.
Tweakers by DirtyGiggles May 21, 2012

Gas Station Tweakers 

Someone who tokes up on "Gas Station Lush" yet, gets the wrong kind of "High".
Damn, niggas tweakin after they smoked that Gas Station Weed, they some Gas Station Tweakers!!!

underground tweakers 

The type of tweaker that goes behind you and mixes up all your organization, robs you, and/or lurks in the shadows and does the unknown worst kind of ugliness and meaness.
Those underground tweakers took our lawn furniture to Tom's and brought his lawn mower over to our pool for a swim last night.

Secret Tweakers 

Two or more seemingly heterosexual female friends, who, are in fact, raving nipple-tweaking lesbians.
Joe "I think Lucy and Jude are Secret Tweakers as neither of them laughed at my hilaroius joke last night"
Secret Tweakers by laurab193 June 1, 2011

Sober Tweakers 

The collection of artists that stay up night drinking Turkish coffee, for real, coffee.
As I distract myself from insomnia....I go online with the others, who paint, dream out loud, write novels, and sing, etc....we end up so much caffeine that we get tweaked out without drugs....and grab out next coffee. We're the sober tweakers #wickedsobah