The couple Spike, a vampire, and Buffy, the slayer, from the Buffy The Vampire Slayer series. Spike fell in love with Buffy and got his soul back for her. Spuffy is the couple with the most unique storyline, best chemistry, and hottest sex scenes.
Term coined to describe the love/hate relationship between "Spike" and "Buffy", two characters played by James Marsters and Sarah Michelle Gellar in the hit series "Buffy The Vampire Slayer".
It is typically used as an adjective in normal conversation to exemplify traits exhibited in their on-screen relationship.