When the toilet is so backed up from your roomate taking giant brick shits that you are forced to shit in a plastic grocery bag and throw it into your roomates room
"Shit in a hand bag" is an expression used when something unexpected happens.
Much like finding a turd inside of a pocketbook this event is of a great surprise to you.
"Shit in a hand bag! I've lost my keys again!!! Shit in a hand bag!"
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.