In the movie Semi-Pro, Jackie Moon tells the referee to suck his cock. He is then ejected and asks the ref about what he said. The ref, being a pastor, says that he said, "s my c."
A line spoken when you know it's time to walk out of the room to leave an uncomfortable situation or argument.
Situation 1:
Wife: I found a xerox box full of porn in the closet. What the hell Jim?
Husband: Well, I wouldn't need porn if you would put out more than once a month!
Me: That's my cue...See you guys later!
Situation 2:
Jill: Eww gross! The dog had diarrhea on the carpet again Sean!
Sean: That's my cue...I'll be at the bar if you need me.
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.