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PuPo is an acronym of sorts that stands for "Pussy Potential". I.e. whether the party is worth coming to, are there girls there. Sometimes you're with a girl when you're on the phone and you can't say, "Tom, are there some sluts there that I can bang?" Instead you would use the term PuPo and Tom could instantly answer yes or no or perhaps go into detail if he feels the need. You typically would ask questions containing PuPo to make sure that the place you're going to isn't a sausage fest.
Tom: Dude, are you coming or what?

Joe: Fuck man I'm all the way down on Bluff, is the PuPo worth it?
Tom: Oh dude the PuPo is out of control. There are at least 30 girls here and only like 10 dudes. That skank Monique is giving everybody lapdances and Sherry has already sucked three cocks. Needless to say, the other girls are down too. There's PuPo here of epic proportions.
Joe: Shit man, you could have just said yes, I love pussy. I'll get in my car as shitfaced as I am and drive there.
PuPo by B Toast October 18, 2010
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A character who comes to your room and vomits on all of your personal items and then leaves without offering to help cleanup.
Kevin was such a Pupo. He left his three course dinner on my mantle, and now Leah has to clean it up.
Pupo by Jill Allshouse March 18, 2005
Related Words
A guy who thinks that the world would and does stop to contemplate his almighty unique thoughts. He's ok though.
Chepi, just how pupo can u be?
pupo by Madeleine February 6, 2004

Basi pupo 

Yall really though this food is real? Its a fake food made by tiktokker and named as a basi pupo and its "from" philippines"
Them: know that food basi pupo
You: yes the tiktoker made it
Them: it looks good
You: its not actual food
Basi pupo by Maxartist February 14, 2022

nubo pupo 

Another way of saying "noob" and your crap. Phrase created by Alejandro Torres AKA Gappingz.
Bro you killed me I was on your team you nubo pupo!
nubo pupo by DankMimsXD April 12, 2019
term used for pritish patel present and to this day.
Hey Pupoo...how much are the hotel prices these days?
pupoo by A to da P September 6, 2008

pupoliguatd 

Put your pussy lips on live i'll give you a thousad dollas
If you wanna make some money Put your pussy lips on live i'll give you a thousand dollars pupoliguatd
pupoliguatd by Maria Davis November 10, 2020