It is a (semi-funny) response, seen a lot on social media like reddit, for example for someone with no chance of surviving a gaming battle due to enemy superior force , originally from 2014 first-person shooter Call of Duty: Advanced Warfare. Quoting know your meme :
"Press F (X) to Pay Respects is an action prompt featured in a quick time event from the 2014 first-person shooter Call of Duty: Advanced Warfare. Upon the release of the game in November 2014, many players of the game mocked the funeral cutscene for its forced element of interactivity that seemed out-of-place at a memorial service."
F "Press F to pay respect"
"Press F (X) to pay respect"
On most computer applications, F1 is the keyboard shortcut to bring up the help menu. Thus, the phrase "Press F1" is most appropriately given as a reply to anybody who needs help, especially in the psychiatric sense.
<Joe> Oh my god, at lunch today, everybody stopped talking and I said, "Crap, the chat died." I really need to stop wasting time on IRC.
<Phil> Dude, you really need help. Seriously. Press F1.
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.
You didn't get any napkins with your takeout pork fried rice? Womp womp.
A phenomenon in film/television series, most notably streaming series, where the main premise is drawn out to such a point that it takes an entire season or more to get the parts of the series the audience is actually interested in seeing.
For example, if a series is titled "Surf Dracula," a majority of viewers would tune in expecting to see Dracula surfing by the first or second episode. However, the entire first season would instead be tedious padding and backstory before finally ending with Dracula surfing in the last five minutes of the season finale.
I watched "Smallville" on Netflix the other day. Dude, it was ten seasons of filler before he finally flew! Major Surf Dracula Syndrome!
Finding your way back to the truth by fixing on one verified fact and working out from there, the way you navigate by the North Star when everything around you is spinning.
Rumours were flying everywhere, so she went northstarring — one checked fact at a time.