Pookeepsie Share definition Flag pookeepsie poo-keep-see v.t. a word used to describe the willful act of self constipation, usually due to time constraints or unsanitary environments. "Oh gosh, guess I need to pull a pookeepsie, I'm so late for work." Pookeepsie by Russ Putnam (WiiTodd) December 25, 2008 Get the Pookeepsie mug.