Man 1: I'm so upset over Angela, I don't know what I'll do!
Man 2: Well that sucks, but Jen is looking pretty cute tonight. She may be the pantidote you're looking for!
A female going without her underwear, i.e without her panties. In the UK and Australia the word normally used to describe the same thing would be knickerless, i.e without her knickers. Also often described as going commando.
When Jane was dancing energetically in the club, it was obvious that she had decided to go out for the evening pantieless.