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Pronounced "Pee Yew" and also spelled "P U" or spelled out "Pfew!", "Phew!," or "Pee-yew!" this aging American interjection, often accompanied with a pinched nose or similar disgusted gesture, indicates the existence of a foul or overpowering odor. Its use seems to have peaked in the mid-Twentieth Century as a semi-euphemism for olfactory revulsion, but is still occasionally used today.
Betty: Archie, what happened to you? P U! (Waves hand in front of face)

Archie (red-faced): I fell in a pickle barrel at the grocery store.

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Sweet Dee Reynolds (in TV show "It's Always Sunny in Philadelphia," ca. 2010): Moms stink! P.U.!!

(episode "Frank Reynolds' Little Beauties," September 29, 2011)
P.U. by al-in-chgo May 24, 2018
Related Words
Silver ITR wheels for sale.
950 shipped or 900 p/u.
p/u by Marcus Thomas December 30, 2006
Literally, "Picture unrelated" Said whenever a picture has nothing to do with the regarding topic. Mostly used in imageboards.
Today was my first day at work. Everything's getting better than before!

p/u
p/u by anonhacks November 2, 2010
Help Help PU alert alert
P.U. by Stina February 17, 2004
"Man, girls, look at those muscles on WC!"
"I knooooww, does he go to P.U. or what?"
P.U. by WC September 15, 2004
Sarah: you saw the cute guy from school?
Jessie: yeah, we are friends... want me to p.u.o?
Sarah: YESSS!
P.U.O by misslea.\ October 24, 2020