A terrible, horrendous mistake of great proportion. Usually pertains to mistakes involving theft, rape, murder, failing in all academic endevours, and basically anything that is not defined as white-collar crime (no pun intended). Comes from the latin words "niggimus mistakumus".
After raping his third girlfriend of the week, D'Mario exclaimed, "I dun made me too many nigstakes this week".
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.