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A terrible, horrendous mistake of great proportion. Usually pertains to mistakes involving theft, rape, murder, failing in all academic endevours, and basically anything that is not defined as white-collar crime (no pun intended). Comes from the latin words "niggimus mistakumus".
After raping his third girlfriend of the week, D'Mario exclaimed, "I dun made me too many nigstakes this week".
Nigstake by D'LeBron November 10, 2008
Related Words

nigstack 

Having a large amount of black chips in Texas Hold'em
Neller is definatly in the chip lead, look at the huge nigstack he has!
nigstack by Catzdontknow September 8, 2005