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a megacon is a mega convention that is held every year in the orlando convention center
megacon is a giant convention in which many people go to dress up as their favorite story characters from shows , movies, anime, and comic books.
megacon by Brooke White February 20, 2007

megacock 

A large penis that is much larger than average, but still smaller than a gigacock and a teracock.
he: what say you polish my megacock, sweetie?
she: totally!
megacock by killerdove November 23, 2011

MegaTokyo 

Webcomic created by Fred "Piro" Gallagher and Rodney "Largo" Caston. After the two fail to get into E3, Piro (anime otaku/japanese dating sim fan) gets a drunk Largo (hardcore gamer/l33t h4x0r m4573r) on a plane to Japan, where they soon find themselves stranded. Eventually, they form relationships with the people around them and find themselves caught in both the struggles to fit in and to get home. An excelent webcomic, though those seeking purely humor may want to visit another comic, such as Penny Arcade.
Have you read the new MegaTokyo strip yet?
MegaTokyo by GuruGuru214 February 1, 2005

megacorndogination 

what happens when your corn dogs get out of control and reproduce mutilated corndog like
due to megacorndogination, corn dogs now rule the world

toxic megacolon 

Acute dilation of the colon, seen in ulcerative colitis.
"You've got toxic megacolon, ASSFACE!!"
toxic megacolon by angelvs August 4, 2007

megatokyo 

The "I wish I was Japense fanclub". It features several main characters:

Piro - The webmaster, artist, and main character of the comic. He is portrayed as a innocent pansy nerd, with a kink for Japanese girls and a obsessive sock fetish. Thankfully, his wussiness has restrained him from several potential scenes of rape throughout the comic, thus keeping the material clean for all readers.

Largo - Stereotypical gamer and avid comptuer overclocker, babbles in nonsensical "l33tsp33k", and due to his constant binging, has incredible resistance to physical punishment, which aids him well in his quest to purge all of Japan of "zombies", possibly a fabrication of his manic America Versus Japan culture clashing.

"The Queen" - Archnemesis of Largo, she posesses formidable skills in gaming, rivaling the disillusioned yankee himself. Intrigued by Largo's stubborness to cling onto his assinine beliefs, much of her story involves a complex silent-romance between her and the unwary Largo.

Hayasaka-San - One of the first friends Piro makes in Japan, she works in a game shop downtown. She keeps to herself about her personal life, and fends off sexual predators with voracious ferocity.

Generic Schoolwhore - A teenager of 16, she too has a crush with Piro, and with the pressure of her two bimbo peers, is forced into a shakey relationship with the reclusive twigboy.
Piro - "Oh my god, I'm so stupid! I should have got her drunk and pinned her down to the floor at the bar and had my way with her. But nooo... I wussed out. Stupid! Stupid! STUPID! Time to drown my sorrows with another drawing of sad girls in snow..."

Largo - "OMGz! U teh fag0rt! I teh l33t mast0rz! Git off me l33t n3tw0rk n0de u teh n00b!"

"The Queen" - "Dark, blackness, consuming me, tearing me up from the inside, can't endure for much longer.... tendrils fingering my asshole.... my sanity is about to crack.... death, darkness, destruction...."

Hayasaka-San - "Get any closer to me and i'll break your other arm!"

Generic Schoolwhore - "Kawaii! Oh my god, your so cute! Cutey Cutey Cutey ^-^! Hey handsome, how about a appointment in my apartment at 1908 Hawasaka Avenue, i'll be dressing in that outfit you like.... meet me at 9:00 sharp, and dress SEXY!"
megatokyo by Chang Tan February 26, 2005