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As said by J-Roc on "Trailer Park Boys", a mafucka is the urban bastardization of motherfucker (q.v.) however its use can vary widely, see example:
"Game's postponed because no mafuckas can go to Canadian Mafucka and get a new orange mafucka for $2.99 !?"
mafucka by J-to-the-R-O-C September 1, 2005
Related Words

muhfucka 

don' mess wit me muhfucka
muhfucka by irishmoron April 27, 2005
Short OG way of saying motherfucker, often used by J-roc from the Trailer Park Boys.
Man throwin' a molotov at the po-po you's a crazy mawfucka!

Check that mawfucka messin' shit up.
Mawfucka by Crazy MF August 19, 2011
Indian Person - "You maufucka!'
maufucka by DigitalMasterDX July 21, 2009
I'm finna get in this mafucka ass
mafucka by duse February 28, 2005

muhfucka 

the word motherfucker, but used by people too lazy to pronounce the 'th' in motherfucker.
you stupid muhfucka!
muhfucka by duckmanx March 15, 2003