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La cagastes 

The Spanish definition for an action that was so stupid that there is no possible remedy or way of atonement for it. Literally interpreted,’ You shit on it', 'it' being what you were attempting to do.
Yo bro, when you grabed your sister-law's ass at the wedding, la cagastes getting along with your mother and father in laws!
La cagastes by Farruco November 19, 2010

Me cago en la puta 

In spanish "I shit on the whore". Commonly use to indicate anger.
Dude, what about the english homework?
!Me cago en la puta!

Yo cago en la leche de tu madre 

I think this is a misquote, it should be 'Me cago en la leche que mamaste' which means "I shit in the milk that you suckled from your mother's breast"
Lovely expression, isn't it? (used widely as 'Me cago en la leche')
The above I have never heard, and anyway this is an English slang dictionary not an Eng - Span one.
Spanish speaker one: Acabo de romper tus gafas (I've just broken your glasses).
Spanish speaker two: Me cago en la leche que mamaste, cabróncete de mierda. (I shit in the milk you suckled from your mother's breast you shitty/fuckin'little bastard.

me cago en la leche 

a shorter way of saying "me cago en la leche de la puta que te date la luz", meaning "i shit in the milk of the whore that bore you," a very common insult in spain.

The sort of thing I learn in spanish class.
"I don't like Harry Potter."
"Well then, me cago en la leche."

Yo cago en la leche de tu madre 

Juan, yo cago en la leche de tu madre.

Me cago en la raja de todos tus muertos 

It's the evolution of me cago en tus muertos and it miens "I shit over your dead parent's ass cracks"
If me cago en tus muertos is really offensive, imagine saying this in a public space... Everyone would kill you
Sometimes it can also be pronounced: me cago'n la raja de tos tus muertos
Person 1: Work you stupid andaluz!
Person 2: Me cago en la raja de todos tus muertos!!! Trabaja tu!!!