Highgraine Share definition Flag The awful hangover like headache one gets from smoking shitty weed. Dude, I smoked a half of that Mexican dirt weed we bought, and all I got from it was a highgraine. Highgraine by Fatfunnyman March 18, 2013 0 0 Get merch Get the Highgraine mug. Buy Now — $32.95 See more merch