Blow one Share definition Flag To "blow" or smoke "one" (one could also mean several in many cases) joint, blunt, cigar, etc. that contain marijuana. Agustin: "Yo Librado Blow One!" Librado: "Oh hell yeah, i got five on it." Blow one by Macjizzy October 15, 2009 0 0 Get merch Get the Blow one mug. Buy Now — $32.95 See more merch