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Are you playing AltF4? 

This phrase is commonly used to respond to someone discussing their personal issues when you have no actual substantial response or advice to give.
Guy 1: "Thing haven't been going so well with the wife ever since I found out she was cheating."

Guy 2: "Are you playing AltF4?"
The mean way to make a newbie quit on windows computers
Newbie: how do i ____?
Dick: Alt+F4
Newbie *quits and is discouraged to play and leaves which slowly makes the community only pros making new people steer away and eventually killing the game as a marketable object*
Alt+F4 by Sleepy_Nerd June 12, 2015
Life saver, Used in computer classes to close windows to save you from being caught doing you aren't supposed to
Guy 1: "Psst! the teacher's coming this way!"
Guy 2: "Alt+F4 Alt+F4!!!!!!
ALT+F4 by ThePhasePhantom November 27, 2012
The biggest life changing function in Windows. Used to close Chrome in Computer Science classes. It is also used in online classes to mute the volume of teacher. Thanks Microsoft for this stuff
My teacher asked me to volume down and I told him to press Alt+F4. I escaped from an online class
Alt+F4 by DankWarrior703 March 21, 2020
The (not so) secret key combo that every teen must know. Pressing Alt+F4 on an active window closes that window instantly, which is useful especially if you're on something you're not supposed to be on. It works on Windows and Linux, however on Mac, you must instead press command + Q, and if you use a Chromebook, the closest you will get to alt+f4 is Ctrl + Shift + Q, which logs you out if pressed two times.
Seriously, Alt+f4 can be a life saver, especially at class or if you have overprotective/strict parents that makes your house look like North Korea
Alt+F4 by GyattDayum23 April 1, 2020
Press "Alt-F4" in World of Warcraft to make your mage cast a vanishing spell.
Alt F4 is a vanishing spell! It really works! Try it; it really makes things disappear. I shit you not.
alt f4 by spinaltapsoundguy May 1, 2010