1) Stands for what the fuck is up?
2) A commercial trying to inform people about "Big Tobacco's crazy ways and addictive products"
2) A commercial trying to inform people about "Big Tobacco's crazy ways and addictive products"
by bockz April 16, 2007

slang that is used to mean "what the fuck is up?"
is also an anti-tobacco ad capaignhttp://www.whudafxup.com/
is also an anti-tobacco ad capaignhttp://www.whudafxup.com/
shelly.. whudafxup w/that?
by dfhdfh September 03, 2008

Whudafxup is a gay commercial.
by BigZaccyStyle September 15, 2006

by rachiebear! October 20, 2006

There is no "is" in whudafxup, figure it out people.
by scamp13 February 07, 2008
