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Fuck's up? 

1.) A more refined way of saying "What the fuck is up?"

2.) A common Michigander greeting.
Fred: Hey Bitch. Fuck's up?
Sally: Not too much.
Fuck's up? by BSliggs June 29, 2011

Fuck's up? 

A different variation of a widely used term,"What's up?"
Person 1: Hey, John.

Person 2: Fuck's up?
Person 1: Not much.
Person 2: Cool, real cool...

Supfucker 

When Josh walked in the house Jonathan said, supfucker.
Supfucker by eeyore357 August 28, 2008

supfuckersshock 

the feeling after using an inappropriate greeting while barging into the wrong party
Matt opened up the door to what he thinks is an open house shouting, "SUP FUCKERS!" only to realize it was an all parent party. Afterwards Matt suffers from extreme levels of supfuckersshock.
supfuckersshock by loveyoucross October 20, 2013

[what's up you mother fucks]

a way to address a room full of people, in a public and/or private place, perhaps after one of those " i just don't give a shit" days.
scene: walking into the break room after you've realized the last 4 hours you've been working have produced nothing but shit.

enter room:
person 1: hey bill whats going on
person 2: bill, BILL, billy boy!
person 3: hey billy

bill: (mumbles) yeah um hum... WHAT'S UP YOU MOTHER FUCKS! hows your day asshole? Mine's turned to shit how about that? :promply walk to the vending machine grab your snack in the midst of the silence and go outside to smoke: