A quadriplegic is someone who has damage (and possible loss) of all four limbs on their body. It is usually caused by brain damage during an accident, where the limbs of the body become useless and need amputation. In a basic version, a quadriplegic is someone who has damage to both/loses both legs and arms during an accident and is just a body and head.
The act of being so incredibly and viciously over intoxicated, that you lose the ability to control your body, on a range from barely able to walk, to barely able to move at all.
I got absolutely quadriplegic drunk last night, I was barely able to get out of bed for days.