muffed up means fucked up. use "muff" to replace fuck. very fun to use so you dont get in trouble by the parentals or offend the old folks. use different variations of muff too-muffer, muffing, etc.
"Fucked-up hoe-bag" as censored by FXM when they air 'The Descendants'
Alexandra King: "Hey, Scottie! Raina's a muffed-up low-bag and you need to stay away from her! And she's going to be a meth-head and she's gonna get used by stupid guys!"
Nickname given to bales of marijuana thrown overboard or out of airplanes. Origin is reportedly from members of the US Coast Guard in the area of Southern Florida.