Trashed, destroyed, zonked, wasted. Usually as the result of ingesting ill-advised substances.
Word entered usage as consequence of backstage graffito "
Drugs,
drugs, loads of
drugs, more drugs, huge amounts of drugs, tons of drugs, even more drugs, huge quantities of drugs...except Largactil which makes me go meep" spotted somewhere in the Glasgow area in late 70's. See also 'meep' defintion someone in there knows what it means.