Meffed is a combination of the words messed and fucked up
Yo go check ya friend he seems a lil meffed up
by Sam A. January 22, 2006
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A term used on 4chan's /lgbt/ board used to refer to masochistic emasculation fetishists, or men who take pleasure in being humiliated by being feminized. See sissy fetishists.
Even though Alice was insecure about her hairline, she refused to wear a wig as she did not want to be confused for an MEF.
by fullbodyphallo October 1, 2022
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"Yo Mef wheres my killa teeth at?"

Dirty Mef (421 the Day After...)

by Jeff Jang October 25, 2006
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mef-derived from the insult meffa or indeed mephloid.
Someone of limited inteligence/extreme clumsyness.
or indeed someone whose limited spacial awareness and general geekiness makes them satnd out from the crowd of geeks
by FITZNICENTIGHTLY October 14, 2004
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Highly skilled gamer, not to be confused with 'meth' or similars.
"mef u want a game of q3 m8?"
by Aaron September 13, 2003
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